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Kambo & Peptide Research 

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The above images are photos taken by me during my visit with the Yawanawa in January 2020 where I had the privileelage of meeting the Kambo frog, Phyllomedusa Bicolor.

The journey of Kambo research began with the pioneering work of Italian scientist Vittorio Erspamer at the University of Rome. Nominated twice for a Nobel Prize, Erspamer not only discovered the neurotransmitter serotonin but also unveiled the extraordinary chemical composition of Kambo. He characterized it as a "fantastic chemical cocktail with potential medical applications, unequalled by any other amphibian."

His groundbreaking findings ignited significant interest in the field of peptides, which have since emerged as vital components in modern medicine. Below is a collection of articles and studies that explore the therapeutic potential of Kambo, highlighting its peptides and their implications for health and wellness.

It is important to recognize that numerous studies exploring the benefits of Kambo are often not published due to rejection by scientific journals. This can be attributed to the controlled nature of our medical system, where natural substances like Kambo may be viewed as competition for pharmaceutical companies that aim to synthesize, patent, and monetize various molecules and drugs. Consequently, much information may remain censored, yet anecdotal evidence continues to emerge, highlighting Kambo's applications for enhancing well-being and facilitating remarkable health transformations.

  1. Acute and subacute psychoactive effects of Kambô, the secretion of the Amazonian Giant Maki Frog (Phyllomedusa bicolor): retrospective reports

  2. Kambô: A Shamanic Medicine, Personal Testimonies

  3. Medical Drug or Shamanic Power Plant: The Uses of Kambô in Brazil

  4. Pharmacological data on dermorphins, a new class of potent opioid peptides from amphibian skin

  5. Antinociceptive effects of dermorphin in animal models of pain

  6. Amphibian skin secretions as a new source of antibiotics and biologically active substances

  7. Rediscovery of old drugs: the forgotten case of dermorphin for postoperative pain and palliation

  8. Spinal action of dermorphin, an extremely potent opioid peptide from frog skin

  9. PHARMACOLOGICAL DATA ON DERMORPHINS, A NEW CLASS OF POTENT OPIOID PEPTIDES FROM AMPHIBIAN SKIN

  10. Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for δ opioid receptors

  11. Peripheral mu-opioid receptor activation by dermorphin [D-Arg2, Lys4] (1–4) amide alleviates behavioral and neurobiological aberrations in rat model of chemotherapy-induced neuropathic pain

  12. ​Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine

  13. Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus

  14. Review of the physiological effects of Phyllomedusa bicolor skin secretion peptides on humans receiving Kambô

  15. Use of Phyllomedusa bicolour secretion during kambô ritual: observational responses, dosage, and risk of adverse events

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